53rd CEMS Colloquium


Prof. Yoshio Okamoto (Nagoya University)


17:30 - 18:30, September 27, 2017 (Wednesday)


Okochi-Hall, RIKEN


Development of Chiral Polymers for Efficient Separation of Enantiomers by HPLC


Many of the biologically or pharmacologically interesting compounds are chiral. These chiral compounds often exhibit different biological activities between the enantiomers. Therefore, to develop chiral drugs, it is necessary to obtain both highly pure enantiomers and to determine enantiomeric purity with trace amounts of samples. The direct separation of enantiomers by high-performance liquid chromatography (HPLC) with chiral stationary phases (CSPs) is the method suitable for these purposes, and in the past few decades, this method has significantly advanced to become a practically useful method. Today, among a large number of the CSPs, the CSPs derived from chiral polymers, particularly cellulose and amylose, are most commonly used. In this lecture, the developments and applications of the CSPs based on the structure control of the polysaccharide derivatives will be mainly discussed.